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・ Interleukin 10 receptor, beta subunit
・ Interleukin 11
・ Interleukin 11 receptor alpha subunit
・ Interleukin 12
・ Interleukin 12 receptor, beta 1 subunit
・ Interleukin 12 receptor, beta 2 subunit
・ Interleukin 12 subunit beta
・ Interleukin 13
・ Interleukin 13 receptor, alpha 1
・ Interleukin 15
・ Interleukin 15 receptor, alpha subunit
・ Interleukin 16
・ Interleukin 17
・ Interleukin 18
・ Interleukin 19
Interleukin 2
・ Interleukin 20
・ Interleukin 20 receptor, alpha subunit
・ Interleukin 20 receptor, beta subunit
・ Interleukin 21
・ Interleukin 22
・ Interleukin 23
・ Interleukin 23 subunit alpha
・ Interleukin 24
・ Interleukin 25
・ Interleukin 26
・ Interleukin 27
・ Interleukin 27 receptor, alpha subunit
・ Interleukin 28
・ Interleukin 28 receptor, alpha subunit


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Interleukin 2 : ウィキペディア英語版
Interleukin 2

Interleukin 2 (IL-2) is an interleukin, a type of cytokine signaling molecule in the immune system. It is a protein that regulates the activities of white blood cells (leukocytes, often lymphocytes) that are responsible for immunity. IL-2 is part of the body's natural response to microbial infection, and in discriminating between foreign ("non-self") and "self". IL-2 mediates its effects by binding to IL-2 receptors, which are expressed by lymphocytes.
== Signaling pathway ==

IL-2 is a member of a cytokine family, each member of which has a four alpha helix bundle; the family also includes IL-4, IL-7, IL-9, IL-15 and IL-21. IL-2 signals through the IL-2 receptor, a complex consisting of three chains, termed alpha, beta and gamma. The gamma chain is shared by all members of this family of cytokine receptors.
The IL-2 Receptor (IL-2R) α subunit has low affinity for its ligand but has the ability (when bound to the β and ϒ subunit) to increase the IL-2R affinity 100-fold. Heterodimerization of the β and ϒ subunits of IL-2R is essential for the signalling in T cells.

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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